Gene

fcho2

ID

ZDB-GENE-050522-228

Name

FCH and mu domain containing endocytic adaptor 2

Symbol

fcho2 Nomenclature History

Previous Names

cb304 (1)
sb:cb304
si:ch211-195c22.1
wu:fa01a02
zgc:112167

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity and phosphatidylserine binding activity. Acts upstream of or within chordate embryonic development and convergent extension involved in axis elongation. Predicted to be located in membrane. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and plasma membrane. Is expressed in anterior axial hypoblast; hatching gland; immature eye; polster; and yolk syncytial layer. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb304 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Umasankar et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fcho2 Human Ortholog

No data available

Associated With fcho2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001060	FCH domain
Domain	IPR018808	Muniscin, C-terminal
Domain	IPR028565	Mu homology domain
Domain	IPR030122	F-BAR domain only protein 2, F-BAR domain
Domain	IPR031160	F-BAR domain
Domain	IPR054713	GMIP/FCHO2-like, FCH domain
Homologous_superfamily	IPR027267	AH/BAR domain superfamily
Homologous_superfamily	IPR036168	AP-2 complex subunit mu, C-terminal superfamily

Domain Details Per Protein

Protein	Length	AH/BAR domain superfamily	AP-2 complex subunit mu, C-terminal superfamily	F-BAR domain	F-BAR domain only protein 2, F-BAR domain	FCH domain	GMIP/FCHO2-like, FCH domain	Mu homology domain	Muniscin, C-terminal
UniProtKB:A0A8M9QDY0 InterPro	1059
UniProtKB:A0A8M9Q8L9 InterPro	1044
UniProtKB:A0A8M9Q3B6 InterPro	862
UniProtKB:A0A8M3ASB7 InterPro	863
UniProtKB:A0A8M2BJ82 InterPro	1018
UniProtKB:A0A8M3B2H5 InterPro	1034
UniProtKB:A0A8M9PXK6 InterPro	1039
UniProtKB:A0A8M3AZM0 InterPro	1033
UniProtKB:A0A8M9PK46 InterPro	1043
UniProtKB:Q502I9 InterPro	848
UniProtKB:A0A8M3B9M8 InterPro	843

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fcho2-201 (1) Ensembl	Ensembl	2,547 nt	Select Tool ZFIN BLAST
mRNA	fcho2-202 (1) Ensembl	Ensembl	4,099 nt	Select Tool ZFIN BLAST
mRNA	fcho2-203 (1) Ensembl	Ensembl	3,291 nt	Select Tool ZFIN BLAST
mRNA	fcho2-204 (1) Ensembl	Ensembl	259 nt	Select Tool ZFIN BLAST
mRNA	fcho2-205 (1) Ensembl	Ensembl	3,379 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations