Gene
letm1
- ID
- ZDB-GENE-050522-154
- Name
- leucine zipper-EF-hand containing transmembrane protein 1
- Symbol
- letm1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable calcium:proton antiporter activity. Predicted to be involved in calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and protein complex oligomerization. Predicted to act upstream of or within calcium ion transport. Predicted to be located in mitochondrial inner membrane. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109969 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Dao et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction | 620089 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | LETM1-like, ribosome-binding domain | LETM1/MDM38-like |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B3G3
|
774 | |||||
|
UniProtKB:A0A8M3BEI6
|
779 | |||||
|
UniProtKB:A0A8M3AYY0
|
785 | |||||
|
UniProtKB:A0A8M3AYW7
|
768 | |||||
|
UniProtKB:Q1LY46
|
757 |
Interactions and Pathways
No data available
Plasmids
No data available