Gene

gsr

ID
ZDB-GENE-050522-116
Name
glutathione reductase
Symbol
gsr Nomenclature History
Previous Names
  • zgc:110010 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have flavin adenine dinucleotide binding activity and glutathione-disulfide reductase activity. Predicted to be involved in cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Is expressed in intestinal bulb; liver; and macrophage. Orthologous to human GSR (glutathione-disulfide reductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gsr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Anemia, congenital, nonspherocytic hemolytic, 10, glutathione reductase deficient 618660
Associated With gsr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Domain IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Domain IPR023753 FAD/NAD(P)-binding domain
Family IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class I
Family IPR006322 Glutathione reductase, eukaryote/bacterial
Family IPR046952 Glutathione reductase/thioredoxin reductase-like
Homologous_superfamily IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length FAD/NAD-linked reductase, dimerisation domain superfamily FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain superfamily Glutathione reductase, eukaryote/bacterial Glutathione reductase/thioredoxin reductase-like Pyridine nucleotide-disulphide oxidoreductase, class I Pyridine nucleotide-disulphide oxidoreductase, class I, active site Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
UniProtKB:Q503Y5 425
UniProtKB:A0A8M6Z2M1 500
UniProtKB:A0A8M9QB21 469
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
aberrant processed transcript gsr-205 (1) Ensembl 870 nt
mRNA gsr-201 (1) Ensembl 1,976 nt
mRNA gsr-202 (1) Ensembl 1,545 nt
mRNA gsr-206 (1) Ensembl 1,318 nt
mRNA gsr-207 (1) Ensembl 895 nt
mRNA gsr-208 (1) Ensembl 660 nt
mRNA gsr-209 (1) Ensembl 1,290 nt
ncRNA gsr-003 (1) Ensembl 814 nt
ncRNA gsr-004 (1) Ensembl 567 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations