Gene
lrp8
- ID
- ZDB-GENE-050506-134
- Name
- low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
- Symbol
- lrp8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in ventral spinal cord development. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in caveola. Is expressed in several structures, including axial hypoblast; brain; immature eye; neural tube; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145907 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Myocardial infarction, susceptibility to} | 608446 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR050685 | Low-density lipoprotein receptor |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Low-density lipoprotein receptor | NOTCH1 EGF-like calcium-binding domain | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BDN7
|
1002 | ||||||||||||
|
UniProtKB:G9MDF3
|
984 | ||||||||||||
|
UniProtKB:A0A8M2BDQ8
|
1008 | ||||||||||||
|
UniProtKB:A0A8M2BDS1
|
978 |
Interactions and Pathways
No data available
Plasmids
No data available