Gene
rad50
- ID
- ZDB-GENE-050506-110
- Name
- RAD50 homolog, double strand break repair protein
- Symbol
- rad50 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable G-quadruplex DNA binding activity; double-stranded telomeric DNA binding activity; and single-stranded telomeric DNA binding activity. Predicted to be involved in chromosome organization and nucleic acid metabolic process. Predicted to act upstream of or within DNA repair and telomere maintenance. Predicted to be located in nucleus. Predicted to be part of Mre11 complex. Predicted to be active in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6906849 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Nijmegen breakage syndrome-like disorder | 613078 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA repair protein Rad50, eukaryotes | P-loop containing nucleoside triphosphate hydrolase | Rad50/SbcC-type AAA domain | RAD50, zinc hook |
|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UW22
|
1312 |
Interactions and Pathways
No data available
Plasmids
No data available