Gene
myoc
- ID
- ZDB-GENE-050425-2
- Name
- myocilin
- Symbol
- myoc Nomenclature History
- Previous Names
-
- zgc:136645
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to be involved in positive regulation of cell migration; regulation of cell-matrix adhesion; and regulation of stress fiber assembly. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Is expressed in caudal fin skeleton; eye; and postcranial axial skeleton. Orthologous to human MYOC (myocilin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from Atienzar-Aroca et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| juvenile glaucoma | Alliance | Glaucoma 1A, primary open angle | 137750 |
| open-angle glaucoma | Alliance | Glaucoma 1A, primary open angle | 137750 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Olfactomedin-like domain | Olfactomedin-like domain-containing protein |
|---|---|---|---|
|
UniProtKB:Q5F0G5
|
474 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available