Gene

dclk2a

ID

ZDB-GENE-050420-170

Name

doublecortin-like kinase 2a

Symbol

dclk2a Nomenclature History

Previous Names

cb572 (1)
dclk2
zDCLK (1)
sb:cb572
si:dkey-180n16.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Exhibits protein serine/threonine kinase activity. Involved in hyperosmotic response and protein autophosphorylation. Localizes to microtubule cytoskeleton; nucleus; and synaptic vesicle. Is expressed in several structures, including hindbrain neural plate; immature eye; nervous system; optic primordium; and trigeminal placode. Orthologous to human DCLK2 (doublecortin like kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb572 (28 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Shimomura et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dclk2a Human Ortholog

No data available

Associated With dclk2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR003533	Doublecortin domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036572	Doublecortin domain superfamily

Domain Details Per Protein

Protein	Length	Doublecortin domain	Doublecortin domain superfamily	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M3AQY6 InterPro	801
UniProtKB:A2A123 InterPro	725
UniProtKB:A2A124 InterPro	722
UniProtKB:A2A121 InterPro	810
UniProtKB:A2A122 InterPro	791

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dclk2a-201 (1) Ensembl	Ensembl	2,294 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-202 (1) Ensembl	Ensembl	4,524 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-203 (1) Ensembl	Ensembl	2,703 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-204 (1) Ensembl	Ensembl	2,642 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-205 (1) Ensembl	Ensembl	2,333 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-206 (1) Ensembl	Ensembl	4,522 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-207 (1) Ensembl	Ensembl	2,490 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-208 (1) Ensembl	Ensembl	2,729 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-211 (1) Ensembl	Ensembl	2,406 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-212 (1) Ensembl	Ensembl	7,324 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-213 (1) Ensembl	Ensembl	2,699 nt	Select Tool ZFIN BLAST
mRNA	dclk2a-214 (1) Ensembl	Ensembl	7,381 nt	Select Tool ZFIN BLAST
ncRNA	dclk2a-005 (1) Ensembl	Ensembl	635 nt	Select Tool ZFIN BLAST
ncRNA	dclk2a-006 (1) Ensembl	Ensembl	486 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations