Gene

akt3a

ID

ZDB-GENE-050419-180

Name

v-akt murine thymoma viral oncogene homolog 3a

Symbol

akt3a Nomenclature History

Previous Names

si:ch211-221n23.2

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Sun et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With akt3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	615937

Associated With akt3a Via Experimental Models

Human Disease	Fish	Conditions	Citations
schizophrenia	akt3a^a229/a229	standard conditions	Thyme et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR017892	Protein kinase, C-terminal
Domain	IPR034675	Protein kinase B gamma, catalytic domain
Domain	IPR039026	Protein Kinase B, pleckstrin homology domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	PH-like domain superfamily	Pleckstrin homology domain	Protein kinase, ATP binding site	Protein kinase B gamma, catalytic domain	Protein Kinase B, pleckstrin homology domain	Protein kinase, C-terminal	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:D9IL79 InterPro	479
UniProtKB:A0A8M9PXW5 InterPro	388

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	akt3a-201 (1) Ensembl	Ensembl	1,147 nt	Select Tool ZFIN BLAST
mRNA	akt3a-203 (1) Ensembl	Ensembl	3,199 nt	Select Tool ZFIN BLAST
ncRNA	akt3a-004 (1) Ensembl	Ensembl	279 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000060693 (1) Ensembl	Ensembl	818 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations