Gene

zgc:110366

ID
ZDB-GENE-050417-302
Name
zgc:110366
Symbol
zgc:110366 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have alditol:NADP+ 1-oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zgc:110366 Human Ortholog
No data available
Associated With zgc:110366 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018170 Aldo/keto reductase, conserved site
Domain IPR023210 NADP-dependent oxidoreductase domain
Family IPR020471 Aldo-keto reductase
Homologous_superfamily IPR036812 NADP-dependent oxidoreductase domain superfamily
Domain Details Per Protein
Protein Length Aldo-keto reductase Aldo/keto reductase, conserved site NADP-dependent oxidoreductase domain NADP-dependent oxidoreductase domain superfamily
UniProtKB:A8DZH9 289
UniProtKB:U3JA33 291
UniProtKB:A0A8M2BAE4 175
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA zgc:110366-201 (1) Ensembl 1,562 nt
mRNA zgc:110366-203 (1) Ensembl 1,066 nt
ncRNA zgc:110366-002 (1) Ensembl 766 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations