Gene
srd5a2b
- ID
- ZDB-GENE-050417-182
- Name
- steroid-5-alpha-reductase, alpha polypeptide 2b
- Symbol
- srd5a2b Nomenclature History
- Previous Names
-
- zgc:112455
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Predicted to be involved in steroid biosynthetic process. Predicted to act upstream of or within cell differentiation; sex differentiation; and steroid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in hindbrain; pectoral fin; and testis. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112455 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pseudovaginal perineoscrotal hypospadias | 264600 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 3-oxo-5-alpha-steroid 4-dehydrogenase | 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal | 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase |
|---|---|---|---|---|
|
UniProtKB:A0A8M2B3D1
|
252 | |||
|
UniProtKB:Q566V2
|
217 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srd5a2b-201
(1)
|
Ensembl | 1,277 nt |
Interactions and Pathways
No data available
Plasmids
No data available