Gene
prkn
- ID
- ZDB-GENE-050417-109
- Name
- parkin RBR E3 ubiquitin protein ligase
- Symbol
- prkn Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitochondrial electron transport, NADH to ubiquinone; protein autoubiquitination; and response to temperature stimulus. Localizes to cytoplasm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Is expressed in digestive system; gill; heart; muscle; and nervous system. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112390 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Flinn et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung cancer | Alliance | Adenocarcinoma of lung, somatic | 211980 |
| ovarian cancer | Alliance | Ovarian cancer, somatic | 167000 |
| Parkinson's disease 2 | Alliance | Parkinson disease, juvenile, type 2 | 600116 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Parkinson's disease | WT + MO1-prkn + MO2-prkn | standard conditions | Flinn et al., 2009 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000626 | Ubiquitin-like domain |
| Domain | IPR002867 | IBR domain |
| Domain | IPR041170 | RING/Ubox-like zinc-binding domain |
| Domain | IPR041565 | Parkin, RING/Ubox like zinc-binding domain |
| Domain | IPR044066 | TRIAD supradomain |
| Domain | IPR047534 | E3 ubiquitin-protein ligase parkin, BRcat domain |
| Domain | IPR047535 | E3 ubiquitin-protein ligase parkin, RING finger, HC subclass |
| Domain | IPR047536 | E3 ubiquitin-protein ligase parkin, Rcat domain |
| Family | IPR003977 | E3 ubiquitin-protein ligase parkin |
| Family | IPR031127 | E3 ubiquitin ligase RBR family |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | E3 ubiquitin ligase RBR family | E3 ubiquitin-protein ligase parkin | E3 ubiquitin-protein ligase parkin, BRcat domain | E3 ubiquitin-protein ligase parkin, Rcat domain | E3 ubiquitin-protein ligase parkin, RING finger, HC subclass | IBR domain | Parkin, RING/Ubox like zinc-binding domain | RING/Ubox-like zinc-binding domain | TRIAD supradomain | Ubiquitin-like domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q561U2
|
458 |
Interactions and Pathways
No data available
Plasmids