Gene

vps33b

ID

ZDB-GENE-050327-73

Name

VPS33B late endosome and lysosome associated

Symbol

vps33b Nomenclature History

Previous Names

zgc:110803

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Involved in intrahepatic bile duct development. Predicted to localize to late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in arthrogryposis, renal dysfunction, and cholestasis 1; cholestasis; and kidney disease. Is expressed in gut; liver; and pancreas. Orthologous to human VPS33B (VPS33B late endosome and lysosome associated).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Matthews et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Matthews et al., 2005
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vps33b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
arthrogryposis, renal dysfunction, and cholestasis 1	Alliance	Arthrogryposis, renal dysfunction, and cholestasis 1	208085
		Cholestasis, progressive familial intrahepatic, 12	620010
		Keratoderma-ichthyosis-deafness syndrome, autosomal recessive	620009

Associated With vps33b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001619	Sec1-like protein
Homologous_superfamily	IPR027482	Sec1-like, domain 2
Homologous_superfamily	IPR036045	Sec1-like superfamily
Homologous_superfamily	IPR043127	Sec1-like, domain 3a
Homologous_superfamily	IPR043154	Sec1-like, domain 1
Homologous_superfamily	IPR043155	Vacuolar protein sorting-associated protein 33, domain 3b