Gene

ikbkg

ID

ZDB-GENE-050327-68

Name

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

Symbol

ikbkg Nomenclature History

Previous Names

ikky (1)
fj33c07
nemo (1)
wu:fj33c07
zgc:113492

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within I-kappaB phosphorylation and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in periderm. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147563 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Davison et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ikbkg Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bloch-Sulzberger syndrome	Alliance	Incontinentia pigmenti	308300
ectodermal dysplasia and immunodeficiency 1	Alliance	Ectodermal dysplasia and immunodeficiency 1	300291
immunodeficiency 33	Alliance	Immunodeficiency 33	300636
		Autoinflammatory disease, systemic, X-linked	301081

Associated With ikbkg Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR021063	NF-kappa-B essential modulator NEMO, N-terminal
Domain	IPR032419	NF-kappa-B essential modulator NEMO, CC2-LZ domain
Domain	IPR034735	NEMO, Zinc finger
Family	IPR051301	Optineurin/NF-kappa-B Essential Modulator

Domain Details Per Protein

Protein	Length	NEMO, Zinc finger	NF-kappa-B essential modulator NEMO, CC2-LZ domain	NF-kappa-B essential modulator NEMO, N-terminal	Optineurin/NF-kappa-B Essential Modulator
UniProtKB:F1QHG7 InterPro	602
UniProtKB:Q58EN3 InterPro	586

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ikbkg-201 (1) Ensembl	Ensembl	2,448 nt	Select Tool ZFIN BLAST
mRNA	ikbkg-202 (1) Ensembl	Ensembl	2,054 nt	Select Tool ZFIN BLAST
mRNA	ikbkg-204 (1) Ensembl	Ensembl	1,812 nt	Select Tool ZFIN BLAST
mRNA	ikbkg-205 (1) Ensembl	Ensembl	1,769 nt	Select Tool ZFIN BLAST
ncRNA	ikbkg-003 (1) Ensembl	Ensembl	830 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations