Gene

lifra

ID

ZDB-GENE-050327-16

Name

LIF receptor subunit alpha a

Symbol

lifra Nomenclature History

Previous Names

zgc:112989

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have cytokine binding activity; peptide hormone binding activity; and prolactin receptor activity. Predicted to be involved in prolactin signaling pathway. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112989 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lifra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Stuve-Wiedemann syndrome/Schwartz-Jampel type 2 syndrome	601559

Associated With lifra Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site
Domain	IPR003961	Fibronectin type III
Domain	IPR040817	Leukemia inhibitory factor receptor, D2 domain
Domain	IPR048497	Leukemia inhibitory factor receptor-like, Ig-like domain
Family	IPR050379	Type I Cytokine Receptor
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like fold	Leukemia inhibitory factor receptor, D2 domain	Leukemia inhibitory factor receptor-like, Ig-like domain	Long hematopoietin receptor, Gp130 family 2, conserved site	Type I Cytokine Receptor
UniProtKB:A0A0R4IE17 InterPro	930

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lifra-201 (1) Ensembl	Ensembl	4,053 nt	Select Tool ZFIN BLAST
mRNA	lifra-202 (1) Ensembl	Ensembl	4,053 nt	Select Tool
mRNA	lifra-203 (1) Ensembl	Ensembl	2,944 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations