Gene

nbeaa

ID

ZDB-GENE-050320-68

Name

neurobeachin a

Symbol

nbeaa Nomenclature History

Previous Names

nbea
im:7138260 (1)
si:ch211-125n11.1
zgc:113510

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable protein kinase binding activity. Involved in synapse organization. Acts upstream of or within dendrite development and synapse assembly. Predicted to be active in cytosol and membrane. Is expressed in nervous system; neural tube; and optic vesicle. Orthologous to human NBEA (neurobeachin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7138260 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Miller et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nbeaa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with or without early-onset generalized epilepsy	619157

Associated With nbeaa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000409	BEACH domain
Domain	IPR010508	Neurobeachin-like, DUF1088
Domain	IPR023362	PH-BEACH domain
Domain	IPR031570	Neurobeachin/BDCP, DUF4704
Domain	IPR046851	Neurobeachin, beta-propeller domain
Domain	IPR046852	Neurobeachin, alpha-solenoid region
Family	IPR050865	BEACH Domain-Containing
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036372	BEACH domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	BEACH domain	BEACH Domain-Containing	BEACH domain superfamily	Concanavalin A-like lectin/glucanase domain superfamily	Neurobeachin, alpha-solenoid region	Neurobeachin/BDCP, DUF4704	Neurobeachin, beta-propeller domain	Neurobeachin-like, DUF1088	PH-BEACH domain	PH-like domain superfamily	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3AWW8 InterPro	2996
UniProtKB:A0A8M3AWZ7 InterPro	2917
UniProtKB:A0A8M3B3E1 InterPro	2970
UniProtKB:A0A8M3AWZ2 InterPro	2962
UniProtKB:A0A8M6Z2X9 InterPro	2223
UniProtKB:A0A8M3B6C6 InterPro	2993
UniProtKB:A0A8M3B6D2 InterPro	2953
UniProtKB:A0A8M3B3E6 InterPro	2951
UniProtKB:A0A8M3BD56 InterPro	2958
UniProtKB:A0A8M3AWX2 InterPro	2956
UniProtKB:E7EZD1 InterPro	2998

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nbeaa-201 (1) Ensembl	Ensembl	10,818 nt	Select Tool ZFIN BLAST
mRNA	nbeaa-202 (1) Ensembl	Ensembl	7,668 nt	Select Tool ZFIN BLAST
mRNA	nbeaa-203 (1) Ensembl	Ensembl	1,821 nt	Select Tool ZFIN BLAST
mRNA	nbeaa-204 (1) Ensembl	Ensembl	3,902 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations