Gene

xrcc3

ID

ZDB-GENE-050320-116

Name

X-ray repair complementing defective repair in Chinese hamster cells 3

Symbol

xrcc3 Nomenclature History

Previous Names

im:7142103
si:dkey-11b8.1
zgc:101608

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to contribute to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to localize to Rad51C-XRCC3 complex and replication fork. Human ortholog(s) of this gene implicated in breast cancer; familial melanoma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101608 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xrcc3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
breast cancer	Alliance	{Breast cancer, susceptibility to}	114480
		{Melanoma, cutaneous malignant, 6}	613972

Associated With xrcc3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013632	DNA recombination and repair protein Rad51-like, C-terminal
Domain	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain
Domain	IPR047348	DNA repair protein XRCC3-like, C-terminal
Family	IPR016467	DNA recombination and repair protein, RecA-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase