Gene
xrcc3
- ID
- ZDB-GENE-050320-116
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 3
- Symbol
- xrcc3 Nomenclature History
- Previous Names
-
- im:7142103
- si:dkey-11b8.1
- zgc:101608
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; ATP-dependent DNA damage sensor activity; and DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of Rad51C-XRCC3 complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); central nervous system cancer (multiple); familial melanoma; multiple myeloma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101608 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | {Breast cancer, susceptibility to} | 114480 |
| {Melanoma, cutaneous malignant, 6} | 613972 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Domain | IPR047348 | DNA repair protein XRCC3-like, C-terminal |
| Family | IPR016467 | DNA recombination and repair protein, RecA-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA recombination and repair protein Rad51-like, C-terminal | DNA recombination and repair protein, RecA-like | DNA recombination and repair protein RecA-like, ATP-binding domain | DNA repair protein XRCC3-like, C-terminal | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5BL30 | InterPro | 352 |
Interactions and Pathways
No data available
Plasmids
No data available