Gene
spen
- ID
- ZDB-GENE-050309-70
- Name
- spen family transcriptional repressor
- Symbol
- spen Nomenclature History
- Previous Names
-
- im:7148349 (1)
- si:ch211-125c5.1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity. Orthologous to human SPEN (spen family transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Rattka et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Radio-Tartaglia syndrome | 619312 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR010912 | Spen paralogue/orthologue C-terminal, metazoa |
| Domain | IPR012921 | Spen paralogue and orthologue SPOC, C-terminal |
| Domain | IPR034172 | SHARP, RNA recognition motif 1 |
| Domain | IPR034173 | SHARP, RNA recognition motif 2 |
| Domain | IPR034174 | SHARP, RNA recognition motif 3 |
| Domain | IPR034175 | SHARP, RNA recognition motif 4 |
| Domain | IPR049093 | Msx2-interacting protein, nuclear receptor-interacting domain |
| Domain | IPR049095 | Msx2-interacting protein, MID domain |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR016194 | SPOC-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Msx2-interacting protein, MID domain | Msx2-interacting protein, nuclear receptor-interacting domain | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | SHARP, RNA recognition motif 1 | SHARP, RNA recognition motif 2 | SHARP, RNA recognition motif 3 | SHARP, RNA recognition motif 4 | Spen paralogue and orthologue SPOC, C-terminal | Spen paralogue/orthologue C-terminal, metazoa | SPOC-like, C-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PQS1
|
3476 | ||||||||||||
|
UniProtKB:A0A8M3AMZ8
|
3475 | ||||||||||||
|
UniProtKB:F1QMN6
|
3476 |
Interactions and Pathways
No data available
Plasmids
No data available