Gene

kdm7ab

ID

ZDB-GENE-050309-32

Name

lysine (K)-specific demethylase 7Ab

Symbol

kdm7ab Nomenclature History

Previous Names

kdm7b (1)
im:7141664
jhdm1D (1)
jhdm1db

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Exhibits histone demethylase activity (H3-K27 specific) and histone demethylase activity (H3-K9 specific). Involved in histone H3-K27 demethylation; histone H3-K9 demethylation; and midbrain development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in melanoma. Is expressed in brain; fin; gill; and tail bud. Orthologous to human KDM7A (lysine demethylase 7A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7141664 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdm7ab Human Ortholog

No data available

Associated With kdm7ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR003347	JmjC domain
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR041070	Jumonji, helical domain
Family	IPR050690	JHDM1 Histone Demethylase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type

Domain Details Per Protein

Protein	Length	JHDM1 Histone Demethylase	JmjC domain	Jumonji, helical domain	Zinc finger, FYVE/PHD-type	Zinc finger, PHD-finger	Zinc finger, PHD-type	Zinc finger, PHD-type, conserved site
UniProtKB:P0CF52 InterPro
UniProtKB:A0A8M1P2J3 InterPro	894
UniProtKB:F1QHF6 InterPro	919

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	kdm7ab-203 (1) Ensembl	Ensembl	264 nt	Select Tool
mRNA	kdm7ab-201 (1) Ensembl	Ensembl	4,852 nt	Select Tool
mRNA	kdm7ab-204 (1) Ensembl	Ensembl	3,457 nt	Select Tool ZFIN BLAST
ncRNA	kdm7ab-003 (1) Ensembl	Ensembl	1,045 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations