Gene

setd1ba

ID

ZDB-GENE-050309-289

Name

SET domain containing 1B, histone lysine methyltransferase a

Symbol

setd1ba Nomenclature History

Previous Names

im:7156157
si:dkey-237o15.4

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable histone H3K4 methyltransferase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in chromosome and nuclear speck. Predicted to be part of Set1C/COMPASS complex. Is expressed in brain; cerebellum; and retinal neural layer. Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7156157 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setd1ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder with seizures and language delay	619000

Associated With setd1ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR001214	SET domain
Domain	IPR003616	Post-SET domain
Domain	IPR024657	COMPASS complex Set1 subunit, N-SET domain
Domain	IPR034468	Set1B, RNA recognition motif
Domain	IPR037841	Histone-lysine N-methyltransferase SETD1A/B-like, SET domain
Family	IPR044570	Histone-lysine N-methyltransferase Set1-like
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	COMPASS complex Set1 subunit, N-SET domain	Histone-lysine N-methyltransferase Set1-like	Histone-lysine N-methyltransferase SETD1A/B-like, SET domain	Nucleotide-binding alpha-beta plait domain superfamily	Post-SET domain	RNA-binding domain superfamily	RNA recognition motif domain	Set1B, RNA recognition motif	SET domain	SET domain superfamily
UniProtKB:A0A8M2BGG2 InterPro	1822
UniProtKB:A0A8M2BGL5 InterPro	1686
UniProtKB:A0A8M3AX93 InterPro	1823
UniProtKB:A0A8M3BDD3 InterPro	1798
UniProtKB:Q1LY77 InterPro	1844
UniProtKB:A0A8M3AX67 InterPro	1568