Gene
scube1
- ID
- ZDB-GENE-050302-78
- Name
- signal peptide, CUB domain, EGF-like 1
- Symbol
- scube1 Nomenclature History
- Previous Names
-
- im:7427863
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Involved in cell surface receptor signaling pathway; muscle fiber development; and primitive hemopoiesis. Localizes to plasma membrane. Is expressed in several structures, including axial chorda mesoderm; blastomere; central nervous system; optic cup; and solid lens vesicle. Orthologous to human SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Domain | IPR024731 | EGF domain |
| Domain | IPR026823 | Complement Clr-like EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR052071 | Signal peptide, CUB and EGF-like domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Complement Clr-like EGF domain | CUB domain | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | NOTCH1 EGF-like calcium-binding domain | Signal peptide, CUB and EGF-like domain-containing protein | Spermadhesin, CUB domain superfamily | Tyrosine-protein kinase ephrin type A/B receptor-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PAA2
|
1024 | ||||||||||||
|
UniProtKB:A0A0R4IBT9
|
994 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
scube1-201
(1)
|
Ensembl | 4,038 nt | ||
| mRNA |
scube1-203
(1)
|
Ensembl | 3,689 nt | ||
| ncRNA |
scube1-002
(1)
|
Ensembl | 1,068 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance