Gene
dyrk1aa
- ID
- ZDB-GENE-050302-29
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
- Symbol
- dyrk1aa Nomenclature History
- Previous Names
-
- dyrk1a
- im:6962097
- zgc:158359
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in brain development. Predicted to localize to nucleus. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Is expressed in endothelial cell; heart; nervous system; and pharyngeal arch. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 7 | Alliance | Intellectual developmental disorder, autosomal dominant 7 | 614104 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | dyrk1aakrb1/krb1 | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P9M8
|
733 | ||||||
|
UniProtKB:A1L1U2
|
737 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dyrk1aa-201
(1)
|
Ensembl | 2,214 nt | ||
| mRNA |
dyrk1aa-203
(1)
|
Ensembl | 695 nt | ||
| mRNA |
dyrk1aa-204
(1)
|
Ensembl | 1,216 nt | ||
| mRNA |
dyrk1aa-206
(1)
|
Ensembl | 3,573 nt | ||
| ncRNA |
dyrk1aa-003
(1)
|
Ensembl | 424 nt | ||
| ncRNA |
dyrk1aa-004
(1)
|
Ensembl | 574 nt |
Interactions and Pathways
No data available
Plasmids