Gene
crebbpb
- ID
- ZDB-GENE-050302-102
- Name
- CREB binding protein b
- Symbol
- crebbpb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable chromatin DNA binding activity; histone acetyltransferase activity; and transcription coactivator activity. Predicted to be involved in histone acetylation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription and rhythmic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in somite. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150488 (1 image)
- dq017638 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Rubinstein-Taybi syndrome | Alliance | Rubinstein-Taybi syndrome 1 | 180849 |
| Menke-Hennekam syndrome 1 | 618332 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR000197 | Zinc finger, TAZ-type |
| Domain | IPR000433 | Zinc finger, ZZ-type |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR003101 | Coactivator CBP, KIX domain |
| Domain | IPR010303 | CREB-binding protein/p300, atypical RING domain |
| Domain | IPR014744 | Nuclear receptor coactivator, CREB-bp-like, interlocking |
| Domain | IPR031162 | CBP/p300-type histone acetyltransferase domain |
| Family | IPR013178 | Histone acetyltransferase Rtt109/CBP |
| Homologous_superfamily | IPR009110 | Nuclear receptor coactivator, interlocking |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR035898 | TAZ domain superfamily |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR036529 | Coactivator CBP, KIX domain superfamily |
| Homologous_superfamily | IPR038547 | CBP/p300, atypical RING domain superfamily |
| Homologous_superfamily | IPR043145 | Zinc finger, ZZ-type superfamily |
Domain Details Per Protein
| Protein | Length | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | CBP/p300, atypical RING domain superfamily | CBP/p300-type histone acetyltransferase domain | Coactivator CBP, KIX domain | Coactivator CBP, KIX domain superfamily | CREB-binding protein/p300, atypical RING domain | Histone acetyltransferase Rtt109/CBP | Nuclear receptor coactivator, CREB-bp-like, interlocking | Nuclear receptor coactivator, interlocking | TAZ domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, TAZ-type | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PUL2
|
2431 | ||||||||||||||||
|
UniProtKB:A0A8M9PNF9
|
2420 | ||||||||||||||||
|
UniProtKB:A0A8M3B0Q0
|
2435 | ||||||||||||||||
|
UniProtKB:A0A8M3AXR2
|
2424 | ||||||||||||||||
|
UniProtKB:A0A8M9Q1N8
|
2321 | ||||||||||||||||
|
UniProtKB:A0A8M3AQ93
|
2325 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
crebbpb-201
(1)
|
Ensembl | 9,022 nt | ||
| mRNA |
crebbpb-202
(1)
|
Ensembl | 12,266 nt |
Interactions and Pathways
No data available
Plasmids
No data available