Gene
baxb
- ID
- ZDB-GENE-050227-21
- Name
- BCL2 associated X, apoptosis regulator b
- Symbol
- baxb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have protein heterodimerization activity and protein homodimerization activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Is expressed in eye; gut; heart; kidney; and ovary. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | T-cell acute lymphoblastic leukemia, somatic | 613065 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q5EAR7
|
207 |
Interactions and Pathways
No data available
Plasmids
No data available