Gene

tcf7

ID

ZDB-GENE-050222-4

Name

transcription factor 7

Symbol

tcf7 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in pectoral fin development; regulation of transcription by RNA polymerase II; and spinal cord dorsal/ventral patterning. Predicted to localize to nucleus and transcription factor complex. Is expressed in several structures, including dermal bone; nervous system; optic cup; pectoral fin bud; and prechordal plate. Orthologous to human TCF7 (transcription factor 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 17 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf7 Human Ortholog

No data available

Associated With tcf7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Domain	IPR013558	CTNNB1 binding, N-teminal
Family	IPR024940	Transcription factor TCF/LEF
Homologous_superfamily	IPR027397	Catenin binding domain superfamily
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Length	Catenin binding domain superfamily	CTNNB1 binding, N-teminal	High mobility group box domain	High mobility group box domain superfamily	Transcription factor TCF/LEF
UniProtKB:Q5PU93 InterPro	355

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tcf7-201 (1) Ensembl	Ensembl	803 nt	Select Tool ZFIN BLAST
mRNA	tcf7-202 (1) Ensembl	Ensembl	924 nt	Select Tool ZFIN BLAST
mRNA	tcf7-203 (1) Ensembl	Ensembl	939 nt	Select Tool ZFIN BLAST
mRNA	tcf7-204 (1) Ensembl	Ensembl	767 nt	Select Tool ZFIN BLAST
mRNA	tcf7-205 (1) Ensembl	Ensembl	792 nt	Select Tool ZFIN BLAST
mRNA	tcf7-206 (1) Ensembl	Ensembl	1,634 nt	Select Tool ZFIN BLAST
mRNA	tcf7-207 (1) Ensembl	Ensembl	1,327 nt	Select Tool ZFIN BLAST
mRNA	tcf7-208 (1) Ensembl	Ensembl	1,643 nt	Select Tool ZFIN BLAST
mRNA	tcf7-209 (1) Ensembl	Ensembl	1,580 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations