Gene
dlg1b
- ID
- ZDB-GENE-050222-3
- Name
- discs large MAGUK scaffold protein 1b
- Symbol
- dlg1b Nomenclature History
- Previous Names
-
- dlg1l
- SAP-97B (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable ionotropic glutamate receptor binding activity; phosphatase binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; endothelial cell proliferation; and negative regulation of G1/S transition of mitotic cell cycle. Predicted to be located in anchoring junction; apical plasma membrane; and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including basolateral plasma membrane; neuromuscular junction; and postsynaptic density membrane. Is expressed in retina; spinal cord; and tegmentum. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu269 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR004172 | L27 domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR015143 | L27-1 |
| Domain | IPR019583 | Disks large homolog 1-4, PDZ-associated domain |
| Domain | IPR019590 | Disks large homologue 1, N-terminal PEST domain |
| Family | IPR016313 | Disks large 1-like |
| Family | IPR050614 | Synaptic Scaffolding LAP/MAGUK Families |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036892 | L27 domain superfamily |
Domain Details Per Protein
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
dlg1l-206
(1)
|
Ensembl | 2,598 nt | ||
| mRNA |
dlg1l-202
(1)
|
Ensembl | 672 nt | ||
| mRNA |
dlg1l-204
(1)
|
Ensembl | 6,958 nt | ||
| mRNA |
dlg1l-205
(1)
|
Ensembl | 2,964 nt | ||
| mRNA |
dlg1l-208
(1)
|
Ensembl | 183 nt | ||
| ncRNA |
dlg1l-003
(1)
|
Ensembl | 796 nt | ||
| ncRNA |
dlg1l-004
(1)
|
Ensembl | 614 nt | ||
| ncRNA |
dlg1l-007
(1)
|
Ensembl | 890 nt |
Interactions and Pathways
No data available
Plasmids
No data available