Gene

dlg2

ID

ZDB-GENE-050221-3

Name

discs, large homolog 2 (Drosophila)

Symbol

dlg2 Nomenclature History

Previous Names

PSD-93 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; negative regulation of phosphatase activity; and receptor clustering. Predicted to colocalize with ionotropic glutamate receptor complex. Is expressed in nervous system and neural tube. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlg2 Human Ortholog

No data available

Associated With dlg2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020590	Guanylate kinase, conserved site
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR004172	L27 domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR015143	L27-1
Domain	IPR019583	Disks large homolog 1-4, PDZ-associated domain
Domain	IPR019590	Disks large homologue 1, N-terminal PEST domain
Domain	IPR035759	Disks Large homologue 2, SH3 domain
Family	IPR016313	Disks large 1-like
Family	IPR050614	Synaptic Scaffolding LAP/MAGUK Families
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036892	L27 domain superfamily

Domain Details Per Protein

Protein	Length	Disks large 1-like	Disks large homolog 1-4, PDZ-associated domain	Disks large homologue 1, N-terminal PEST domain	Disks Large homologue 2, SH3 domain	Guanylate kinase, conserved site	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	L27-1	L27 domain	L27 domain superfamily	PDZ domain	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily	Synaptic Scaffolding LAP/MAGUK Families
UniProtKB:A0A8M3B3D7 InterPro	858
UniProtKB:A0A8M3B6B1 InterPro	1044
UniProtKB:A0A8M3BD50 InterPro	959
UniProtKB:A0A8M3BD41 InterPro	987
UniProtKB:A0A8M3AWU6 InterPro	1068
UniProtKB:A0A8M3AWX6 InterPro	1031
UniProtKB:A0A8M3B6A6 InterPro	1065
UniProtKB:A0A8M3B6B8 InterPro	972
UniProtKB:A0A8M3B6B4 InterPro	1010
UniProtKB:A0A8M3BD31 InterPro	1075
UniProtKB:A0A8M3AWV4 InterPro	1022
UniProtKB:A0A8M9QC28 InterPro	860
UniProtKB:A0A8M3AWW9 InterPro	1075
UniProtKB:A0A8M3B3D0 InterPro	1002
UniProtKB:A0A8M3AWX1 InterPro	1060
UniProtKB:A0A8M3AWW5 InterPro	931
UniProtKB:A0A8M3BD47 InterPro	961
UniProtKB:Q5PYH7 InterPro	881
UniProtKB:A0A8M3B6C1 InterPro	925
UniProtKB:A0A8M3B3C7 InterPro	1042
UniProtKB:A0A8M3AWY5 InterPro	967
UniProtKB:A0A8M3AWY0 InterPro	987
UniProtKB:A0A8M3AWV0 InterPro	1057
UniProtKB:A0A8M3BD37 InterPro	1030
UniProtKB:A0A8M3B3C4 InterPro	1063
UniProtKB:A0A8M3B3D4 InterPro	968
UniProtKB:A0A8M3AWY7 InterPro	1040
UniProtKB:A0A8M3AWW1 InterPro	977
UniProtKB:A0A8M3B3C1 InterPro	1083
UniProtKB:A0A8M3BD36 InterPro	1059