Gene

pmpcb

ID

ZDB-GENE-050220-10

Name

peptidase, mitochondrial processing subunit beta

Symbol

pmpcb Nomenclature History

Previous Names

zgc:110738 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to contribute to endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to localize to mitochondrial inner membrane and mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110738 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pmpcb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
multiple mitochondrial dysfunctions syndrome 6	Alliance	Multiple mitochondrial dysfunctions syndrome 6	617954

Associated With pmpcb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR001431	Peptidase M16, zinc-binding site
Domain	IPR007863	Peptidase M16, C-terminal
Domain	IPR011765	Peptidase M16, N-terminal
Family	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex
Homologous_superfamily	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like

Domain Details Per Protein

Protein	Length	Metalloenzyme, LuxS/M16 peptidase-like	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex	Peptidase M16, C-terminal	Peptidase M16, N-terminal	Peptidase M16, zinc-binding site
UniProtKB:Q5EB15 InterPro	470

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pmpcb-201 (1) Ensembl	Ensembl	1,625 nt	Select Tool ZFIN BLAST
ncRNA	pmpcb-002 (1) Ensembl	Ensembl	789 nt	Select Tool ZFIN BLAST
ncRNA	pmpcb-003 (1) Ensembl	Ensembl	732 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations