Gene

frem1b

ID

ZDB-GENE-050208-783

Name

Fras1 related extracellular matrix 1b

Symbol

frem1b Nomenclature History

Previous Names

si:ch211-219p7.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within cell communication. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix. Is expressed in blood island. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With frem1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Bifid nose with or without anorectal and renal anomalies	608980
		Manitoba oculotrichoanal syndrome	248450
		Trigonocephaly 2	614485

Associated With frem1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001304	C-type lectin-like
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Domain	IPR045658	FRAS1-related extracellular matrix protein, N-terminal domain
Family	IPR051561	FRAS1-related extracellular matrix
Homologous_superfamily	IPR016186	C-type lectin-like/link domain superfamily
Homologous_superfamily	IPR016187	C-type lectin fold
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Repeat	IPR039005	CSPG repeat

Domain Details Per Protein

Protein	Length	CalX-like domain superfamily	CSPG repeat	C-type lectin fold	C-type lectin-like	C-type lectin-like/link domain superfamily	FRAS1-related extracellular matrix	FRAS1-related extracellular matrix protein, N-terminal domain	Na-Ca exchanger/integrin-beta4
UniProtKB:B6IDE5 InterPro	2167
UniProtKB:F1R2T2 InterPro	2137

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	frem1b-201 (1) Ensembl	Ensembl	6,591 nt	Select Tool ZFIN BLAST
mRNA	frem1b-202 (1) Ensembl	Ensembl	6,625 nt	Select Tool ZFIN BLAST
mRNA	frem1b-203 (1) Ensembl	Ensembl	6,678 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations