Gene

osbpl1a

ID

ZDB-GENE-050208-657

Name

oxysterol binding protein-like 1A

Symbol

osbpl1a Nomenclature History

Previous Names

si:dkey-121a11.8

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have cholesterol binding activity and sterol transporter activity. Predicted to be involved in lipid transport. Predicted to localize to cytosol; intracellular membrane-bounded organelle; and membrane. Used to study visceral heterotaxy. Orthologous to human OSBPL1A (oxysterol binding protein like 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Burkhalter et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Burkhalter et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With osbpl1a Human Ortholog

No data available

Associated With osbpl1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
visceral heterotaxy	WT + MO1-osbpl1a	standard conditions	Burkhalter et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018494	Oxysterol-binding protein, conserved site
Domain	IPR001849	Pleckstrin homology domain
Family	IPR000648	Oxysterol-binding protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037239	Oxysterol-binding protein superfamily
Repeat	IPR002110	Ankyrin repeat