Gene
ptprc
- ID
- ZDB-GENE-050208-585
- Name
- protein tyrosine phosphatase receptor type C
- Symbol
- ptprc Nomenclature History
- Previous Names
-
- cd45 (1)
- sb:eu845
- si:dkeyp-47c5.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of protein kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; and protein dephosphorylation. Predicted to act upstream of or within dephosphorylation. Predicted to be located in membrane. Is expressed in blood island; common myeloid progenitor; hematopoietic stem cell; intermediate cell mass of mesoderm; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in multiple sclerosis; primary immunodeficiency disease; and severe combined immunodeficiency. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu845 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency 105, severe combined | 619924 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available