Gene

bap1

ID

ZDB-GENE-050208-492

Name

BRCA1 associated deubiquitinase 1

Symbol

bap1 Nomenclature History

Previous Names

si:dkey-42i9.9

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have chromatin binding activity and thiol-dependent ubiquitin-specific protease activity. Involved in Notch signaling pathway and cranial skeletal system development. Predicted to localize to PR-DUB complex and cytoplasm. Human ortholog(s) of this gene implicated in basal cell carcinoma. Orthologous to human BAP1 (BRCA1 associated protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu310 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bap1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
uveal melanoma	Alliance	{Uveal melanoma, susceptibility to, 2}	606661
		Kury-Isidor syndrome	619762
		Tumor predisposition syndrome 1	614327

Associated With bap1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001578	Peptidase C12, ubiquitin carboxyl-terminal hydrolase
Domain	IPR041507	Peptidase C12, C-terminal domain
Homologous_superfamily	IPR036959	Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily