Gene

eef2a.2

ID

ZDB-GENE-050208-348

Name

eukaryotic translation elongation factor 2a, tandem duplicate 2

Symbol

eef2a.2 Nomenclature History

Previous Names

si:dkey-110c1.4

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have GTPase activity; ribosome binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to localize to cytosol and ribonucleoprotein complex. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eef2a.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia type 26	Alliance	?Spinocerebellar ataxia 26	609306

Associated With eef2a.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR031157	Tr-type G domain, conserved site
Domain	IPR000640	Elongation factor EFG, domain V-like
Domain	IPR000795	Translational (tr)-type GTP-binding domain
Domain	IPR004161	Translation elongation factor EFTu-like, domain 2
Domain	IPR005225	Small GTP-binding domain
Domain	IPR005517	Translation elongation factor EFG/EF2, domain IV
Domain	IPR041095	Elongation Factor G, domain II
Homologous_superfamily	IPR009000	Translation protein, beta-barrel domain superfamily
Homologous_superfamily	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR035647	EF-G domain III/V-like

Domain Details Per Protein

Protein	Length	EF-G domain III/V-like	Elongation factor EFG, domain V-like	Elongation Factor G, domain II	P-loop containing nucleoside triphosphate hydrolase	Ribosomal protein uS5 domain 2-type superfamily	Small GTP-binding domain	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Translational (tr)-type GTP-binding domain	Translation elongation factor EFG/EF2, domain IV	Translation elongation factor EFTu-like, domain 2	Translation protein, beta-barrel domain superfamily	Tr-type G domain, conserved site
UniProtKB:Q1LYG6 InterPro	853

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	eef2a.2-201 (1) Ensembl	Ensembl		3,143 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: This gene and eef2a.1 (ZDB-GENE-050522-500) are right next to each other in the genome and are likely the result of a tandem duplication. The genes show high amino acid identity and conserved location with human EEF2 and mouse Eef2.

Citations