Gene
lmx1bb
- ID
- ZDB-GENE-050114-2
- Name
- LIM homeobox transcription factor 1, beta b
- Symbol
- lmx1bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in animal organ development and glutamatergic neuron differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in nail-patella syndrome. Is expressed in several structures, including axis; midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; nervous system; and otic vesicle. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nail-patella syndrome | Alliance | Nail-patella syndrome | 161200 |
| Focal segmental glomerulosclerosis 10 | 256020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q4VJ29
|
375 | |||||
|
UniProtKB:Q4L1M6
|
375 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lmx1bb-201
(1)
|
Ensembl | 1,952 nt | ||
| mRNA |
lmx1bb-203
(1)
|
Ensembl | 3,812 nt | ||
| ncRNA |
lmx1bb-002
(1)
|
Ensembl | 697 nt |
Interactions and Pathways
No data available
Plasmids
No data available