Gene

eda

ID

ZDB-GENE-050107-6

Name

ectodysplasin A

Symbol

eda Nomenclature History

Previous Names

nackt (1)
nkt (1)
si:ch73-223d24.5 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have tumor necrosis factor receptor binding activity. Involved in bone development and odontogenesis. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Is expressed in dental mesenchyme; integument; pharyngeal arch; and pharynx. Orthologous to human EDA (ectodysplasin A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eda Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
ectodermal dysplasia 1	Alliance	Ectodermal dysplasia 1, hypohidrotic, X-linked	305100
tooth agenesis	Alliance	Tooth agenesis, selective, X-linked 1	313500

Associated With eda Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006052	Tumour necrosis factor domain
Family	IPR051748	Tumor Necrosis Factor Ligand Superfamily
Homologous_superfamily	IPR008983	Tumour necrosis factor-like domain superfamily