Gene

tfr1b

ID

ZDB-GENE-041220-2

Name

transferrin receptor 1b

Symbol

tfr1b Nomenclature History

Previous Names

tfrc (1)
CD71

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable transferrin receptor activity. Acts upstream of or within cellular iron ion homeostasis and hemoglobin biosynthetic process. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu958 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Wingert et al., 2004
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfr1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 46	Alliance	Immunodeficiency 46	616740

Associated With tfr1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003137	PA domain
Domain	IPR007484	Peptidase M28
Domain	IPR037324	Transferrin receptor protein 1/2, PA domain
Family	IPR039373	Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Homologous_superfamily	IPR036757	Transferrin receptor-like, dimerisation domain superfamily
Homologous_superfamily	IPR046450	PA domain superfamily