Gene
prnpa
- ID
- ZDB-GENE-041217-6
- Name
- prion protein a (Kanno blood group)
- Symbol
- prnpa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Exhibits copper ion binding activity and superoxide dismutase activity. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Is expressed in heart; neuromast; pectoral fin; and pharyngeal arch 3-7 skeleton. Orthologous to human PRNP (prion protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cotto et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Creutzfeldt-Jakob disease | Alliance | Creutzfeldt-Jakob disease | 123400 |
| fatal familial insomnia | Alliance | Insomnia, fatal familial | 600072 |
| Gerstmann-Straussler-Scheinker syndrome | Alliance | Cerebral amyloid angiopathy, PRNP-related | 137440 |
| Gerstmann-Straussler-Scheinker syndrome | Alliance | Gerstmann-Straussler disease | 137440 |
| Huntington's disease-like 1 | Alliance | Huntington disease-like 1 | 603218 |
| Spongiform encephalopathy with neuropsychiatric features | 606688 | ||
| {Kuru, susceptibility to} | 245300 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Length |
|---|---|
|
UniProtKB:Q7T2P9
|
188 |
Interactions and Pathways
No data available
Plasmids
No data available