Gene

dhcr24

ID

ZDB-GENE-041212-73

Name

24-dehydrocholesterol reductase

Symbol

dhcr24 Nomenclature History

Previous Names

zgc:101638

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have delta24(24-1) sterol reductase activity. Predicted to be involved in steroid metabolic process. Predicted to localize to cytoplasm and membrane. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Is expressed in cranial ganglion; lens; solid lens vesicle; telencephalon; and yolk syncytial layer. Orthologous to human DHCR24 (24-dehydrocholesterol reductase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101638 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dhcr24 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Desmosterolosis	602398

Associated With dhcr24 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006094	FAD linked oxidase, N-terminal
Domain	IPR016166	FAD-binding domain, PCMH-type
Family	IPR040165	Delta(24)-sterol reductase
Homologous_superfamily	IPR016169	FAD-binding, type PCMH, subdomain 2
Homologous_superfamily	IPR036318	FAD-binding, type PCMH-like superfamily