Gene

pax4

ID

ZDB-GENE-041210-244

Name

paired box 4

Symbol

pax4 Nomenclature History

Previous Names

DKEY-146J3.4 (1)
si:dkey-146j3.3

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have sequence-specific DNA binding activity. Involved in endocrine pancreas development; glucose homeostasis; and pancreas regeneration. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Is expressed in endocrine system and stomodeum. Orthologous to human PAX4 (paired box 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pax4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
diabetic ketoacidosis	Alliance	{Diabetes mellitus, ketosis-prone, susceptibility to}	612227
maturity-onset diabetes of the young type 9	Alliance	Maturity-onset diabetes of the young, type IX	612225
type 2 diabetes mellitus	Alliance	Diabetes mellitus, type 2	125853

Associated With pax4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR001523	Paired domain
Domain	IPR043182	Paired DNA-binding domain
Family	IPR043565	PAX family
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily