Gene
pde3a
- ID
- ZDB-GENE-041210-23
- Name
- phosphodiesterase 3A, cGMP-inhibited
- Symbol
- pde3a Nomenclature History
- Previous Names
-
- si:dkey-48h7.2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in oocyte and oocyte stage V. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pang et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypertension and brachydactyly syndrome | Alliance | Hypertension and brachydactyly syndrome | 112410 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003607 | HD/PDEase domain |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | HD/PDEase domain |
|---|---|---|---|---|---|---|
| UniProtKB:F6P4K3 | InterPro | 1117 | ||||
| UniProtKB:A0A8M3ARD3 | InterPro | 1123 | ||||
| UniProtKB:A0A8M3B8Q1 | InterPro | 1124 | ||||
| UniProtKB:A0A8M3AYI3 | InterPro | 1106 |
Interactions and Pathways
No data available
Plasmids
No data available