Gene
socs2
- ID
- ZDB-GENE-041210-171
- Name
- suppressor of cytokine signaling 2
- Symbol
- socs2 Nomenclature History
- Previous Names
-
- si:dkey-202b22.1
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor binding activity. Predicted to be involved in cytokine-mediated signaling pathway and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within intracellular signal transduction and negative regulation of signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001496 | SOCS box domain |
| Domain | IPR028410 | Suppressor of cytokine signalling 2, SOCS box domain |
| Domain | IPR035862 | SOCS2, SH2 domain |
| Homologous_superfamily | IPR036036 | SOCS box-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | SH2 domain | SH2 domain superfamily | SOCS2, SH2 domain | SOCS box domain | SOCS box-like domain superfamily | Suppressor of cytokine signalling 2, SOCS box domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B0EVP5
|
197 | ||||||
|
UniProtKB:A0A8M3ARE8
|
198 |
Interactions and Pathways
No data available
Plasmids
No data available