Gene

foxp1b

ID

ZDB-GENE-041203-1

Name

forkhead box P1b

Symbol

foxp1b Nomenclature History

Previous Names

foxp1 (1)
im:7139058
wu:fc83a06

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity; metal ion binding activity; and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; peritonitis; and schizophrenia. Is expressed in several structures, including gut; hatching gland; nervous system; pericardial region; and pleuroperitoneal region. Orthologous to human FOXP1 (forkhead box P1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7139058 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxp1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
intellectual disability-severe speech delay-mild dysmorphism syndrome	Alliance	Intellectual developmental disorder with language impairment with or without autistic features	613670

Associated With foxp1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR032354	FOXP, coiled-coil domain
Domain	IPR047412	Forkhead box protein P1/P2, forkhead domain
Family	IPR050998	Forkhead box protein P
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Forkhead box protein P	Forkhead box protein P1/P2, forkhead domain	Fork head domain	Fork head domain conserved site 2	FOXP, coiled-coil domain	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A8M9PM82 InterPro	675
UniProtKB:Q2LE08 InterPro	659
UniProtKB:A0A8M9Q673 InterPro	676
UniProtKB:A0A8M9PZW2 InterPro	660
UniProtKB:A0A8M3ATJ4 InterPro	535

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	foxp1b-201 (1) Ensembl	Ensembl	2,428 nt	Select Tool
mRNA	foxp1b-202 (1) Ensembl	Ensembl	2,338 nt	Select Tool ZFIN BLAST
mRNA	foxp1b-205 (1) Ensembl	Ensembl	486 nt	Select Tool
mRNA	foxp1b-208 (1) Ensembl	Ensembl	923 nt	Select Tool
mRNA	foxp1b-209 (1) Ensembl	Ensembl	2,046 nt	Select Tool ZFIN BLAST
mRNA	foxp1b-210 (1) Ensembl	Ensembl	2,933 nt	Select Tool ZFIN BLAST
mRNA	foxp1b-211 (1) Ensembl	Ensembl	2,411 nt	Select Tool ZFIN BLAST
ncRNA	foxp1b-004 (1) Ensembl	Ensembl	2,406 nt	Select Tool
ncRNA	foxp1b-005 (1) Ensembl	Ensembl	759 nt	Select Tool
ncRNA	foxp1b-006 (1) Ensembl	Ensembl	967 nt	Select Tool
ncRNA	foxp1b-007 (1) Ensembl	Ensembl	777 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations