Gene
gna11b
- ID
- ZDB-GENE-041121-9
- Name
- guanine nucleotide binding protein (G protein), alpha 11b (Gq class)
- Symbol
- gna11b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in G protein-coupled receptor signaling pathway; entrainment of circadian clock; and phototransduction, visible light. Predicted to localize to heterotrimeric G-protein complex and photoreceptor outer segment. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Is expressed in barbel; brain; gill; lip; and sensory system. Orthologous to human GNA11 (G protein subunit alpha 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant hypocalcemia 2 | Alliance | Hypocalcemia, autosomal dominant 2 | 615361 |
| familial hypocalciuric hypercalcemia 2 | Alliance | Hypocalciuric hypercalcemia, type II | 145981 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000654 | G-protein alpha subunit, group Q |
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | G-protein alpha subunit, group Q | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
|
UniProtKB:Q5RKP9
|
359 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gna11b-201
(1)
|
Ensembl | 2,381 nt |
Interactions and Pathways
No data available
Plasmids
No data available