Gene
ftsj1
- ID
- ZDB-GENE-041114-83
- Name
- FtsJ RNA 2'-O-methyltransferase 1
- Symbol
- ftsj1 Nomenclature History
- Previous Names
-
- fb17g12
- wu:fb17g12
- zgc:101831
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable tRNA methyltransferase activity. Predicted to be involved in cytoplasmic translation and tRNA methylation. Predicted to act upstream of or within RNA methylation and tRNA processing. Predicted to be active in cytoplasm. Is expressed in cerebellum and heart. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101831 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 9 | Alliance | Intellectual developmental disorder, X-linked 9 | 309549 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002877 | Ribosomal RNA methyltransferase, FtsJ domain |
| Family | IPR015507 | Ribosomal RNA large subunit methyltransferase E |
| Family | IPR028590 | tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase TRM7 |
| Family | IPR050082 | Ribosomal RNA large subunit methyltransferase RlmE |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
Domain Details Per Protein
| Protein | Length | Ribosomal RNA large subunit methyltransferase E | Ribosomal RNA large subunit methyltransferase RlmE | Ribosomal RNA methyltransferase, FtsJ domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily | tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase TRM7 |
|---|---|---|---|---|---|---|
|
UniProtKB:A8E5E3
|
323 | |||||
|
UniProtKB:F1QDU3
|
323 | |||||
|
UniProtKB:Q5U3P4
|
323 |
Interactions and Pathways
No data available
Plasmids
No data available