Gene
mvk
- ID
- ZDB-GENE-041114-37
- Name
- mevalonate kinase
- Symbol
- mvk Nomenclature History
- Previous Names
-
- zgc:103473
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have mevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Is expressed in liver. Orthologous to human MVK (mevalonate kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyperimmunoglobulinemia D periodic fever syndrome | Alliance | Hyper-IgD syndrome | 260920 |
| mevalonic aciduria | Alliance | Mevalonic aciduria | 610377 |
| Porokeratosis 3, multiple types | 175900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006203 | GHMP kinase, ATP-binding, conserved site |
| Domain | IPR006204 | GHMP kinase N-terminal domain |
| Domain | IPR013750 | GHMP kinase, C-terminal domain |
| Family | IPR006205 | Mevalonate kinase |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036554 | GHMP kinase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | GHMP kinase, ATP-binding, conserved site | GHMP kinase, C-terminal domain | GHMP kinase, C-terminal domain superfamily | GHMP kinase N-terminal domain | Mevalonate kinase | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5U3I7
|
396 |
Interactions and Pathways
No data available
Plasmids
No data available