Gene

mvk

ID

ZDB-GENE-041114-37

Name

mevalonate kinase

Symbol

mvk Nomenclature History

Previous Names

zgc:103473

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have mevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Is expressed in liver. Orthologous to human MVK (mevalonate kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mvk Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hyperimmunoglobulinemia D periodic fever syndrome	Alliance	Hyper-IgD syndrome	260920
mevalonic aciduria	Alliance	Mevalonic aciduria	610377
		Porokeratosis 3, multiple types	175900

Associated With mvk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR006203	GHMP kinase, ATP-binding, conserved site
Domain	IPR006204	GHMP kinase N-terminal domain
Domain	IPR013750	GHMP kinase, C-terminal domain
Family	IPR006205	Mevalonate kinase
Homologous_superfamily	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR036554	GHMP kinase, C-terminal domain superfamily