Gene
ppm1db
- ID
- ZDB-GENE-041114-27
- Name
- protein phosphatase, Mg2+/Mn2+ dependent, 1Db
- Symbol
- ppm1db Nomenclature History
- Previous Names
-
- zgc:103518 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of gene expression, epigenetic and regulation of intracellular signal transduction. Predicted to act upstream of or within protein dephosphorylation. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103518 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | Breast cancer, somatic | 114480 |
| Jansen-de Vries syndrome | 617450 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PPM-type phosphatase, divalent cation binding | PPM-type phosphatase-like domain | PPM-type phosphatase-like domain superfamily | Protein phosphatase 2C |
|---|---|---|---|---|---|
|
UniProtKB:Q5U3H7
|
534 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppm1db-201
(1)
|
Ensembl | 1,894 nt |
Interactions and Pathways
No data available
Plasmids
No data available