Gene

fbxl4

ID

ZDB-GENE-041114-187

Name

F-box and leucine-rich repeat protein 4

Symbol

fbxl4 Nomenclature History

Previous Names

zgc:92297

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Used to study mitochondrial DNA depletion syndrome 13. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92297 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fbxl4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial DNA depletion syndrome 13	Alliance	Mitochondrial DNA depletion syndrome 13 (encephalomyopathic type)	615471

Associated With fbxl4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
mitochondrial DNA depletion syndrome 13	fbxl4^{sa12470/sa12470}	standard conditions	Lavorato et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001810	F-box domain
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036047	F-box-like domain superfamily
Repeat	IPR006553	Leucine-rich repeat, cysteine-containing subtype