Gene
cln3
- ID
- ZDB-GENE-041114-174
- Name
- CLN3 lysosomal/endosomal transmembrane protein, battenin
- Symbol
- cln3 Nomenclature History
- Previous Names
-
- zgc:92244 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Involved in axonogenesis; lysosome organization; and negative regulation of neuron apoptotic process. Predicted to localize to lysosome. Used to study neuronal ceroid lipofuscinosis 3. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Is expressed in brain; central nervous system; cerebellum; and midbrain hindbrain boundary. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92244 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Wager et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neuronal ceroid lipofuscinosis 3 | Alliance | Ceroid lipofuscinosis, neuronal, 3 | 204200 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| neuronal ceroid lipofuscinosis 3 | TL + MO1-cln3 | standard conditions | Wager et al., 2016 |
| neuronal ceroid lipofuscinosis 3 | TL + MO2-cln3 | standard conditions | Wager et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Batten's disease protein Cln3 | Batten's disease protein Cln3, subgroup | MFS transporter superfamily |
|---|---|---|---|---|
|
UniProtKB:Q5U392
|
446 |
Interactions and Pathways
No data available
Plasmids