Gene
prdm12b
- ID
- ZDB-GENE-041114-172
- Name
- PR domain containing 12b
- Symbol
- prdm12b Nomenclature History
- Previous Names
-
- zgc:101606
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity; DNA-binding transcription factor activity; and histone methyltransferase binding activity. Involved in hematopoietic progenitor cell differentiation; primitive erythrocyte differentiation; and ventral spinal cord interneuron specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 8. Is expressed in several structures, including basal plate midbrain region; hindbrain neural keel; midbrain neural keel; nervous system; and neurogenic placode. Orthologous to human PRDM12 (PR/SET domain 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101606 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 8 | Alliance | Neuropathy, hereditary sensory and autonomic, type VIII | 616488 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001214 | SET domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR044406 | PRDM12, PR/SET domain |
| Family | IPR017126 | PR-domain zinc finger protein PRDM12 |
| Family | IPR050331 | Zinc finger |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | PRDM12, PR/SET domain | PR-domain zinc finger protein PRDM12 | SET domain | SET domain superfamily | Zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5U3V3
|
366 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available