Gene
prdm12b
- ID
- ZDB-GENE-041114-172
- Name
- PR domain containing 12b
- Symbol
- prdm12b Nomenclature History
- Previous Names
-
- zgc:101606
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable histone methyltransferase binding activity. Acts upstream of or within hemopoiesis; negative regulation of transcription by RNA polymerase II; and ventral spinal cord interneuron specification. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; central nervous system; cranial ganglion; ectoderm; and midbrain neural keel. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 8. Orthologous to human PRDM12 (PR/SET domain 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101606 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 8 | Alliance | Neuropathy, hereditary sensory and autonomic, type VIII | 616488 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001214 | SET domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR044406 | PRDM12, PR/SET domain |
| Family | IPR017126 | PR-domain zinc finger protein PRDM12 |
| Family | IPR050331 | Zinc finger |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | PRDM12, PR/SET domain | PR-domain zinc finger protein PRDM12 | SET domain | SET domain superfamily | Zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5U3V3
|
366 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prdm12b-201
(1)
|
Ensembl | 3,027 nt |
Interactions and Pathways
No data available
Plasmids
No data available