Gene
mvda
- ID
- ZDB-GENE-041114-127
- Name
- mevalonate (diphospho) decarboxylase a
- Symbol
- mvda Nomenclature History
- Previous Names
-
- zgc:100824 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have diphosphomevalonate decarboxylase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:100824 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Wong et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Porokeratosis 7, multiple types | 614714 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR041431 | Mvd1, C-terminal |
Domain | IPR053859 | Diphosphomevalonate decarboxylase-like N-terminal domain |
Family | IPR005935 | Diphosphomevalonate/phosphomevalonate decarboxylase |
Family | IPR029765 | Diphosphomevalonate decarboxylase |
Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
Homologous_superfamily | IPR036554 | GHMP kinase, C-terminal domain superfamily |
Domain Details Per Protein
Protein | Length | Diphosphomevalonate decarboxylase | Diphosphomevalonate decarboxylase-like N-terminal domain | Diphosphomevalonate/phosphomevalonate decarboxylase | GHMP kinase, C-terminal domain superfamily | Mvd1, C-terminal | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q5U403
|
400 |
Interactions and Pathways
No data available
Plasmids
No data available