Gene

angptl4

ID

ZDB-GENE-041111-222

Name

angiopoietin-like 4

Symbol

angptl4 Nomenclature History

Previous Names

fiaf (1)
im:7144703
si:rp71-39b20.7 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable enzyme inhibitor activity. Acts upstream of or within apoptotic process involved in blood vessel morphogenesis and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in endocrine pancreas; intestinal epithelium; intestine; and liver. Orthologous to human ANGPTL4 (angiopoietin like 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144703 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Serbanovic-Canic et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With angptl4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Plasma triglyceride level QTL, low	615881

Associated With angptl4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Family	IPR050373	Fibrinogen C-terminal domain-containing protein
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal

Domain Details Per Protein

Protein	Length	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Fibrinogen, conserved site	Fibrinogen C-terminal domain-containing protein	Fibrinogen-like, C-terminal
UniProtKB:A0A8M1NYZ0 InterPro	460

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	angptl4-202 (1) Ensembl	Ensembl	2,397 nt	Select Tool ZFIN BLAST
ncRNA	angptl4-002 (1) Ensembl	Ensembl	224 nt	Select Tool ZFIN BLAST
ncRNA	angptl4-003 (1) Ensembl	Ensembl	492 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations